Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 4/20 | 0.46 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571041 | 0.86 | HTR2A (0.50) | SRD5A1HTR2AHTR2CHTR2BTDP1 | |
| SCHEMBL7796406 | 0.79 | SRD5A1 (0.46) | SRD5A1HTR2AHTR2CPARP10 | |
| SCHEMBL7796246 | 0.79 | HTR2A (0.49) | SRD5A1HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL20229607 | 0.78 | SRD5A1 (0.43) | SRD5A1CAMK2ATDP1L3MBTL1PARP10 | |
| SCHEMBL12272087 | 0.78 | ADRA2A (0.43) | SRD5A1CAMK2AHTR2AHTR2CTDP1 | |
| SCHEMBL30527308 | 0.78 | SRD5A1 (0.43) | SRD5A1CAMK2ATDP1L3MBTL1PARP10 | |
| SCHEMBL6249142 | 0.76 | HTR2C (0.51) | SRD5A1HTR2AHTR2CHTR2BBRD4 | |
| SCHEMBL948086 | 0.73 | ACP3 (0.46) | SRD5A1HTR2AHTR2CHTR2BADRA2B | |
| SCHEMBL13948754 | 0.72 | SRD5A1 (0.49) | SRD5A1CAMK2AHTR2AHTR2CHTR2B | |
| SCHEMBL10024954 | 0.72 | SRD5A1 (0.49) | SRD5A1CAMK2AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| EP-0343830-B1 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | LILLY CO ELI (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5026707-A | Antiserotonine agents | ELI LILLY AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0343830-A2 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |