SCHEMBL948086

SCHEMBL948086

CC1C(=O)CCc2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP3 P15309 1/20 0.46
HTR2A P28223 3/20 0.44
RET P07949 1/20 0.44
HTR2C P28335 2/20 0.43
HTR2B P41595 1/20 0.43
ANPEP P15144 2/20 0.42
PDPK1 O15530 1/20 0.41
CHRM1 P11229 1/20 0.41
DRD2 P14416 1/20 0.41
ADRA2B P18089 1/20 0.41
ADRA2C P18825 1/20 0.41
CHRM3 P20309 1/20 0.41
ADRA1A P35348 1/20 0.41
HRH1 P35367 1/20 0.41
DRD3 P35462 1/20 0.41
KCNH2 Q12809 1/20 0.41
SRD5A1 P18405 2/20 0.40
CES1 P23141 1/20 0.40
PRCP P42785 1/20 0.39
CYP2A6 P11509 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8746509 0.84 HTR2A (0.52) ACP3HTR2ARETHTR2CHTR2B
SCHEMBL2187484 0.81 ANPEP (0.59) HTR2AHTR2CANPEPHRH1ACHE
SCHEMBL30633009 0.81 ANPEP (0.59) HTR2AHTR2CANPEPHRH1ACHE
SCHEMBL9385590 0.78 ACP3 (0.48) ACP3HTR2ARETANPEPPDPK1
SCHEMBL21311775 0.77 CYP2A6 (0.44) ACP3HTR2ARETHTR2CHTR2B
SCHEMBL27844077 0.77 MEN1 (0.37) CES1
SCHEMBL7124003 0.77 ACP3 (0.47) ACP3HTR2ARETANPEPPDPK1
SCHEMBL8901794 0.77 ACP3 (0.47) ACP3HTR2ARETANPEPPDPK1
SCHEMBL529484 0.75 ACP3 (0.46) ACP3HTR2ARETANPEPPDPK1
SCHEMBL6916099 0.75 ACP3 (0.50) ACP3HTR2ARETANPEPCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591583-B1 Benzo (f) quinolinones as 5-alpha-reductase inhibitors LILLY CO ELI (US) 2001-12-19 EP claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0532190-B1 Benzo(f)quinolinones as 5-alpha-reductase inhibitors LILLY CO ELI (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
CN-1039320-C Process for preparing hexahydro-and octahydro-benzo [ f ] quinolinones and optical isomers thereof LILLY CO ELI (US) 1998-07-29 CN claimed
EP-0507001-B1 A process for the preparation of nepinalone BIOINDUSTRIA SPA (IT) 1997-09-17 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0591583-A1 Benzo (f) quinolinones as 5-alpha-reductase inhibitors ELI LILLY AND COMPANY (US) 1994-04-13 EP claimed
US-5239075-A PROCESS FOR THE PREPARATION OF BENZO (F) QUINOLINONES ELI LILLY AND COMPANY (US) 1993-08-24 US claimed
CN-1071418-A Benzo [ f ] quinolinones LILLY CO ELI (US) 1993-04-28 CN claimed
EP-0532190-A2 Benzo f quinolinones as 5-alpha-reductase inhibitors ELI LILLY AND COMPANY (US) 1993-03-17 EP claimed
EP-0507001-A1 A process for the preparation of nepinalone BIOINDUSTRIA FARMACEUTICI S.p.A. (IT) 1992-10-07 EP claimed
US-4493904-A COORDINATION, POLYMERIZATION CATALYST CONTAINING TITANIUM TRICHORI CONOCO INC. (US) 1985-01-15 US claimed
JP-5239032-A None JP disclosed
EP-3495363-B1 NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT SHIONOGI & CO (JP) 2023-08-23 EP disclosed
US-3937736-A ANALGESICS, ANTIINFLAMMATORY AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1976-02-10 US disclosed
US-3931328-A CARBURETOR AMERICAN HOME PRODUCTS CORPORATION (US) 1976-01-06 US disclosed