Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115602 | 0.84 | SLC18A3 (0.38) | SLC6A2HTR2C | |
| SCHEMBL8124405 | 0.82 | MKNK1 (0.34) | SLC6A3KDM1AMAOBHTR2C | |
| SCHEMBL8125702 | 0.82 | PRCP (0.33) | KDM1A | |
| SCHEMBL8131566 | 0.81 | SLC6A2 (0.38) | SLC6A4SLC6A2SLC6A3DRD2CYP2D6 | |
| SCHEMBL8125817 | 0.81 | KDM1A (0.34) | SLC6A4SLC6A2SLC6A3KDM1AMAOB | |
| SCHEMBL8126345 | 0.81 | KDM4E (0.33) | SLC6A4SLC6A2SLC6A3MAOAHTR2C | |
| SCHEMBL8124867 | 0.81 | SLC6A2 (0.36) | SLC6A4SLC6A2SLC6A3HTR6HTR2C | |
| SCHEMBL8124794 | 0.81 | SLC6A2 (0.36) | SLC6A4SLC6A2SLC6A3HTR6HTR2C | |
| SCHEMBL8125194 | 0.80 | SLC6A2 (0.32) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8131062 | 0.80 | HTR3A (0.39) | SLC6A4SLC6A2SLC6A3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | claimed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | claimed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |