Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8128908 | 1.00 | ROCK2 (0.45) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL8125211 | 1.00 | ROCK2 (0.45) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL7460734 | 0.89 | MTNR1A (0.47) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL6976070 | 0.88 | MTNR1A (0.45) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL6973598 | 0.88 | MTNR1A (0.45) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL6964736 | 0.88 | MTNR1A (0.46) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL8128824 | 0.88 | MTNR1A (0.46) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL6966393 | 0.88 | MTNR1A (0.48) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL11335708 | 0.88 | MTNR1A (0.48) | ROCK2MTNR1AMTNR1BKCNH2NCF1 | |
| SCHEMBL11344192 | 0.88 | MTNR1A (0.48) | ROCK2MTNR1AMTNR1BKCNH2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |