Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126130 | 0.89 | TDP1 (0.44) | LMNATDP1ALDH1A1SMN1; SMN2CHRNB2 | |
| SCHEMBL8143440 | 0.87 | TDP1 (0.46) | LMNATDP1ALDH1A1SMN1; SMN2CHRNB2 | |
| SCHEMBL8143883 | 0.85 | TDP1 (0.51) | LMNATDP1CYP19A1KMT2A | |
| SCHEMBL8130021 | 0.82 | CYP19A1 (0.47) | LMNATDP1ALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL9799454 | 0.81 | LMNA (0.50) | LMNATDP1ALDH1A1SMN1; SMN2CHRNB2 | |
| SCHEMBL8124461 | 0.78 | LMNA (0.50) | LMNATDP1ALDH1A1SMN1; SMN2CHRNB2 | |
| SCHEMBL8124416 | 0.78 | LMNA (0.50) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL8124770 | 0.78 | LMNA (0.50) | LMNATDP1ALDH1A1SMN1; SMN2CHRNB2 | |
| SCHEMBL16301357 | 0.77 | LMNA (0.68) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 | |
| SCHEMBL8126088 | 0.76 | LMNA (0.45) | LMNATDP1ALDH1A1SMN1; SMN2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |