SCHEMBL8129236

SCHEMBL8129236

COC(=O)CC([C]=O)OC(=O)C(N)C(C)C

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PSMB5 P28074 1/20 0.33
SLC7A5 Q01650 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
SLC15A1 P46059 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8148377 0.86 DPP4 (0.36)
SCHEMBL8120548 0.86 MGAM (0.38) PSMB5SLC7A5SLC15A1
SCHEMBL8127263 0.80 PRKCA (0.32)
SCHEMBL8127262 0.80 PRKCA (0.32)
SCHEMBL8127674 0.80 SLC7A5 (0.35) SLC7A5
SCHEMBL8127759 0.78 SLC7A5 (0.34) SLC7A5
SCHEMBL8130193 0.78 SLC7A5 (0.34) PSMB5SLC7A5
SCHEMBL8129257 0.77 DPP7 (0.43) SLC7A5MAPTSLC15A1
SCHEMBL8127873 0.77 SLC15A1 (0.59) SLC15A1
SCHEMBL10382930 0.75 MGAM (0.38) MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054891-A1 PRODRUGS MEDIVIR AB (SE) 2000-11-29 EP disclosed
WO-1999041275-A1 PRODRUGS MEDIVIR AB (SE) 1999-08-19 WO disclosed