Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119996 | 0.94 | LPAR1 (0.41) | L3MBTL1KMT2AALDH1A1MAPTLPAR1 | |
| SCHEMBL8131084 | 0.93 | LPAR1 (0.41) | L3MBTL1KMT2AALDH1A1MAPTLPAR1 | |
| SCHEMBL8128380 | 0.93 | KMT2A (0.39) | L3MBTL1KMT2AALDH1A1LMNAHPGD | |
| SCHEMBL8121344 | 0.92 | LPAR1 (0.42) | L3MBTL1KMT2AALDH1A1MAPTLPAR1 | |
| SCHEMBL8148224 | 0.91 | ALDH1A1 (0.38) | L3MBTL1ALDH1A1LMNAHPGDMAPT | |
| SCHEMBL8129418 | 0.90 | KMT2A (0.37) | L3MBTL1KMT2AALDH1A1LPAR1MAPK1 | |
| SCHEMBL8129485 | 0.90 | MAPK1 (0.38) | L3MBTL1KMT2ALPAR1MAPK1 | |
| SCHEMBL8120272 | 0.89 | KMT2A (0.39) | L3MBTL1KMT2ALMNAHPGDMAPK1 | |
| SCHEMBL8128937 | 0.89 | KMT2A (0.40) | L3MBTL1KMT2AMAPK1 | |
| SCHEMBL8129666 | 0.89 | L3MBTL1 (0.42) | L3MBTL1KMT2AALDH1A1MAPTLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |