Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8122035 | 0.92 | LNPEP (0.40) | L3MBTL1KMT2AERAP2LNPEPGAA | |
| SCHEMBL8128937 | 0.91 | KMT2A (0.40) | L3MBTL1KMT2AMAPK1PDE4APDE4B | |
| SCHEMBL8119996 | 0.91 | LPAR1 (0.41) | L3MBTL1KMT2AMAPK1ALDH1A1KDM4E | |
| SCHEMBL8129666 | 0.91 | L3MBTL1 (0.42) | L3MBTL1KMT2AMAPK1ERAP2LNPEP | |
| SCHEMBL8129705 | 0.91 | L3MBTL1 (0.40) | L3MBTL1KMT2AMAPK1ERAP2LNPEP | |
| SCHEMBL8131084 | 0.91 | LPAR1 (0.41) | L3MBTL1KMT2AMAPK1GAATDP1 | |
| SCHEMBL8130312 | 0.91 | KMT2A (0.39) | L3MBTL1KMT2AMAPK1ERAP2LNPEP | |
| SCHEMBL8149905 | 0.91 | NR1H4 (0.35) | L3MBTL1ERAP2LNPEPGAATDP1 | |
| SCHEMBL8127088 | 0.90 | L3MBTL1 (0.42) | L3MBTL1KMT2AMAPK1ERAP2LNPEP | |
| SCHEMBL8121992 | 0.90 | KMT2A (0.42) | L3MBTL1KMT2AMAPK1ERAP2LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |