Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130408 | 0.91 | THRA (0.43) | FFAR1PLA2G4BTHRATHRBTSHR | |
| SCHEMBL8120029 | 0.91 | FFAR1 (0.47) | FFAR1PLA2G4BTHRATHRBTSHR | |
| SCHEMBL8136073 | 0.88 | PPARG (0.43) | FFAR1PLA2G4BTHRATHRBTSHR | |
| SCHEMBL8119916 | 0.86 | CYSLTR2 (0.45) | FFAR1MMP9CYSLTR2CYSLTR1 | |
| SCHEMBL8132595 | 0.85 | FFAR1 (0.40) | FFAR1PLA2G4BTHRATHRBTSHR | |
| SCHEMBL8126572 | 0.85 | CYSLTR2 (0.47) | FFAR1TSHRMMP9MMP13CYSLTR2 | |
| SCHEMBL8428047 | 0.84 | PLA2G4B (0.44) | PLA2G4BTHRATHRBTSHRPPARG | |
| SCHEMBL8119424 | 0.83 | FFAR1 (0.40) | FFAR1TSHRMMP9CYSLTR2CYSLTR1 | |
| SCHEMBL8136349 | 0.83 | FFAR1 (0.50) | FFAR1 | |
| SCHEMBL8119415 | 0.83 | FFAR1 (0.38) | FFAR1PLA2G4BTHRATHRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |