Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.50 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129124 | 0.97 | FFAR1 (0.51) | FFAR1CTRCKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL8121730 | 0.92 | FFAR1 (0.51) | FFAR1MAOB | |
| SCHEMBL8120029 | 0.89 | FFAR1 (0.47) | FFAR1KMT2ASMN1; SMN2 | |
| SCHEMBL8121726 | 0.88 | FFAR1 (0.48) | FFAR1MAOB | |
| SCHEMBL8119916 | 0.86 | CYSLTR2 (0.45) | FFAR1 | |
| SCHEMBL8126572 | 0.85 | CYSLTR2 (0.47) | FFAR1 | |
| SCHEMBL8130408 | 0.85 | THRA (0.43) | FFAR1 | |
| SCHEMBL8119424 | 0.83 | FFAR1 (0.40) | FFAR1 | |
| SCHEMBL8129258 | 0.83 | FFAR1 (0.43) | FFAR1 | |
| SCHEMBL8799205 | 0.83 | ALDH1A1 (0.40) | FFAR1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |