Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.57 |
| ▸ | CHRNA10 | Q9GZZ6 | 5/20 | 0.57 |
| ▸ | CHRNA9 | Q9UGM1 | 5/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80826 | 0.94 | CHRNA7 (0.63) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL17561642 | 0.90 | CHRNA7 (0.52) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL80066 | 0.89 | CHRNA7 (0.65) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL81218 | 0.89 | CHRNA7 (0.58) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| Bromide SCHEMBL69311 | 0.88 | CHRNA7 (0.62) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL17561643 | 0.85 | CHRNA7 (0.61) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL80814 | 0.83 | CHRNA7 (0.72) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL17561668 | 0.80 | CHRNA7 (0.66) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL16418454 | 0.76 | ESR1 (0.66) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| Bromide SCHEMBL16414995 | 0.74 | ESR1 (0.64) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031607-A1 | WATER-SOLUBLE AIE LUMINOGENS FOR MONITORING AND RETARDATION OF FIBRILLATION OF AMYLOID PROTEINS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-01-29 | — | — | US | disclosed |
| US-8679738-B2 | Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-03-25 | — | — | US | disclosed |
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2012-07-05 | — | — | US | disclosed |
| US-8129111-B2 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2012-03-06 | — | — | US | disclosed |
| US-7939613-B2 | Probes/sensors for biomacromolecules; films; cosmetics | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2011-05-10 | — | — | US | disclosed |
| US-20100009362-A1 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-01-14 | — | — | US | disclosed |
| US-20080220407-A1 | Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | IAPP, IGF2BP1, IGF2BP2 | CHRNA7 4379/4885CHRNA10 3582/4885CHRNA9 4259/4885 |
| US-20080220407-A1 | Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | FUS, CD63, EPCAM | CHRNA7 4056/4885CHRNA10 3266/4885CHRNA9 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.