Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 13/20 | 0.58 |
| ▸ | CHRNA10 | Q9GZZ6 | 5/20 | 0.58 |
| ▸ | CHRNA9 | Q9UGM1 | 5/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.53 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80826 | 0.94 | CHRNA7 (0.63) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL81293 | 0.89 | CHRNA7 (0.57) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL80814 | 0.86 | CHRNA7 (0.72) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL17561668 | 0.82 | CHRNA7 (0.66) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL79978 | 0.81 | ESRRG (0.52) | ESR1MAPTKDM4EMEN1TP53 | |
| SCHEMBL17561642 | 0.80 | CHRNA7 (0.52) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL80066 | 0.79 | CHRNA7 (0.65) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| Bromide SCHEMBL69311 | 0.78 | CHRNA7 (0.62) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL15101927 | 0.77 | LTA4H (0.63) | ESR1MAPTMEN1TP53CYP1A2 | |
| SCHEMBL10153479 | 0.76 | TP53 (0.63) | MAPTTP53ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9279806-B2 | Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-03-08 | — | — | US | disclosed |
| US-20150031607-A1 | WATER-SOLUBLE AIE LUMINOGENS FOR MONITORING AND RETARDATION OF FIBRILLATION OF AMYLOID PROTEINS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-01-29 | — | — | US | disclosed |
| US-8679738-B2 | Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-03-25 | — | — | US | disclosed |
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2012-07-05 | — | — | US | disclosed |
| US-8129111-B2 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2012-03-06 | — | — | US | disclosed |
| US-20100009362-A1 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | IAPP, IGF2BP1, IGF2BP2 | CHRNA7 4379/4885CHRNA10 3582/4885CHRNA9 4259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.