Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.60 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.60 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 3/20 | 0.60 |
| ▸ | CA9 | Q16790 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.60 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.60 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.60 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.60 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.60 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350366 | 0.88 | CA12 (0.55) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL5359827 | 0.88 | CA12 (0.55) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8141475 | 0.86 | CA12 (0.54) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8135744 | 0.86 | CA12 (0.57) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8137077 | 0.86 | CA12 (0.54) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL8136133 | 0.86 | CA12 (0.54) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL13624125 | 0.84 | MAPT (0.75) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL3827659 | 0.82 | KDM4E (0.67) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| SCHEMBL6037182 | 0.80 | GRIA2 (0.61) | MAPTGRIA2GRIA1GRIA3GRIA4 | |
| Dnqx SCHEMBL594575 | 0.76 | GRIA2 (1.00) | MAPTGRIA2GRIA1GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760819-B1 | TRICYCLIC DICARBONYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2000-07-19 | — | — | EP | disclosed |
| US-5688803-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0760819-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032205-A1 | TRICYCLIC DICARBONYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-30 | — | — | WO | disclosed |