Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 4/20 | 0.61 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.61 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.61 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.61 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.61 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129404 | 0.80 | MAPT (0.60) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL13197693 | 0.79 | TDP1 (0.50) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| Dnqx SCHEMBL594575 | 0.76 | GRIA2 (1.00) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL13624125 | 0.76 | MAPT (0.75) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL9390031 | 0.74 | GRIN2D (0.58) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL6757995 | 0.73 | GABRP (0.52) | MAPTSIRT2KIF11GABRPGABRD | |
| SCHEMBL8688932 | 0.73 | TSHR (0.55) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL30554364 | 0.70 | MAPT (0.44) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL20916841 | 0.70 | MAPT (0.44) | GRIA2GRIA1GRIA3GRIA4CYP1A2 | |
| SCHEMBL9479012 | 0.69 | MAPT (0.49) | GRIA2GRIA1GRIA3GRIA4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060070135-A1 | Compositions and methods for inhibiting the enzymatic activity of PTP-1B | TREMBLAY MICHEL | 2006-03-30 | — | — | US | disclosed |