Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15730254 | 0.95 | LMNA (0.49) | LMNAMAPTPGRDDB1CRBN | |
| SCHEMBL11876733 | 0.78 | KDM4E (0.59) | LMNAMAPTPGRDDB1CRBN | |
| SCHEMBL3648904 | 0.78 | LMNA (0.48) | LMNAMAPTPGRALDH1A1SMN1; SMN2 | |
| SCHEMBL15723841 | 0.76 | LMNA (0.46) | LMNAMAPTPOLB | |
| SCHEMBL20371571 | 0.76 | LMNA (0.46) | LMNAMAPTPGRCYP1A2ALDH1A1 | |
| SCHEMBL1492377 | 0.74 | LMNA (0.44) | LMNAMAPTALDH1A1 | |
| SCHEMBL14487357 | 0.70 | APEX1 (0.56) | LMNAMAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8564358 | 0.70 | LMNA (1.00) | LMNAMAPTCYP1A2ALDH1A1SMN1; SMN2 | |
| SCHEMBL29798837 | 0.70 | CYP1A2 (0.55) | LMNAPGRCYP1A2ERCC1FEN1 | |
| SCHEMBL474339 | 0.70 | CYP1A2 (0.55) | LMNAPGRCYP1A2ERCC1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |