Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.41 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352315 | 0.92 | CYP19A1 (0.50) | CYP19A1DGAT1PPARD | |
| SCHEMBL467521 | 0.80 | ACHE (0.55) | CYP19A1DGAT1TP53L3MBTL1SIGMAR1 | |
| Bromide SCHEMBL8113723 | 0.80 | CYP19A1 (0.49) | CYP19A1DGAT1PPARD | |
| SCHEMBL924439 | 0.76 | CYP19A1 (0.46) | CYP19A1PPARD | |
| SCHEMBL21145504 | 0.73 | PPARD (0.48) | PPARD | |
| SCHEMBL8535642 | 0.71 | CYP19A1 (0.58) | CYP19A1DGAT1TP53SIGMAR1ACHE | |
| SCHEMBL3311293 | 0.70 | HDAC1 (0.46) | KDM4CKDM5AKDM5BTP53L3MBTL1 | |
| SCHEMBL9737731 | 0.70 | TP53 (0.41) | DGAT1TP53L3MBTL1 | |
| SCHEMBL21145509 | 0.70 | PPARD (0.51) | PPARD | |
| SCHEMBL27999226 | 0.69 | DGAT1 (0.38) | CYP19A1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015450-A1 | NOVEL PYRIDAZINE COMPOUNDS | AstraZeneca UK Limited (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-1997045428-A1 | NOVEL PYRIDAZINE COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-12-04 | — | — | WO | disclosed |