Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 4/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 8/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131449 | 1.00 | STAT3 (0.56) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL9096957 | 1.00 | STAT3 (0.56) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL4675138 | 0.91 | STAT3 (0.49) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL4730859 | 0.91 | STAT3 (0.49) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL8744082 | 0.90 | GSK3B (0.45) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL4673103 | 0.90 | GSK3B (0.53) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL8139161 | 0.90 | GSK3B (0.53) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL8007897 | 0.90 | GSK3B (0.45) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL7997875 | 0.90 | GSK3B (0.45) | STAT3MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL5619172 | 0.90 | GSK3B (0.53) | STAT3MEN1KMT2ATOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545642-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-13 | — | — | US | claimed |
| EP-0653425-A1 | 1-(2-Fluorocyclopropyl)-quinolone- and naphthyridone carboxylic acid derivatives, their preparation and their use as antibacterials | BAYER AG (DE) | 1995-05-17 | — | — | EP | claimed |
| EP-0704443-B1 | Quinolone and naphthyridone carboxylic acid derivatives | BAYER AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| EP-0705828-B1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1999-12-01 | — | — | EP | disclosed |
| US-5990122-A | SUBSTITUTED IN THE 7-POSITION BY A TRICYCLIC AMINE RADICAL; REDUCED GENOTOXIC PROPERTIES AND INCREASED ANTIBACTERIAL ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-23 | — | — | US | disclosed |
| US-5986105-A | ENANTIOMORPHS AS BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-16 | — | — | US | disclosed |
| US-5783708-A | HEXAHYDROISOINDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| US-5753669-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |
| US-5703094-A | Quinolone- and naphthyridonecarboxylic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1997-12-30 | — | — | US | disclosed |
| EP-0721948-B1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1997-12-03 | — | — | EP | disclosed |
| US-5679689-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |
| US-5605910-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-25 | — | — | US | disclosed |
| US-5545642-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-13 | — | — | US | disclosed |
| EP-0721948-A1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1996-07-17 | — | — | EP | disclosed |
| EP-0705828-A1 | Quinolone- and naphthyridone carboxylic acid derivatives as antibacterial agents | BAYER AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| EP-0704443-A2 | Quinolone and naphthyridone carboxylic acid derivatives | BAYER AG (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0653425-A1 | 1-(2-Fluorocyclopropyl)-quinolone- and naphthyridone carboxylic acid derivatives, their preparation and their use as antibacterials | BAYER AG (DE) | 1995-05-17 | — | — | EP | disclosed |