Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934273 | 0.89 | MAPT (0.55) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL28470897 | 0.86 | MAPT (0.56) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL4262200 | 0.85 | LMNA (0.66) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL4534294 | 0.84 | ADAM17 (0.66) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL11293629 | 0.83 | MAPT (0.55) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL28470775 | 0.82 | MAPT (0.50) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL6929216 | 0.82 | KDM4E (0.53) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL28472602 | 0.81 | MAPT (0.46) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL6077411 | 0.81 | LMNA (0.53) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL28475863 | 0.77 | HTT (0.48) | MAPTLMNASMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147110-A | MELATONINERGIC AGENTS; SLEEP, EATING, CENTRAL NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-11-14 | — | — | US | disclosed |
| EP-0926145-A1 | Napthalene compounds, method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-30 | — | — | EP | disclosed |