Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.60 |
| ▸ | ACHE | P22303 | 4/20 | 0.60 |
| ▸ | CNR1 | P21554 | 3/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318882 | 0.93 | CNR2 (0.67) | CNR2ACHECNR1PLA2G2ALMNA | |
| SCHEMBL3322212 | 0.87 | CNR1 (0.64) | CNR2ACHECNR1PLA2G2AL3MBTL1 | |
| SCHEMBL1163283 | 0.80 | CNR2 (0.56) | CNR2ACHECNR1MAPT | |
| SCHEMBL264907 | 0.77 | ADORA2A (0.54) | CNR2ACHECNR1LMNAL3MBTL1 | |
| SCHEMBL7119866 | 0.76 | CNR2 (0.81) | CNR2ACHECNR1LMNAMEN1 | |
| SCHEMBL7116425 | 0.75 | CNR2 (1.00) | CNR2ACHECNR1 | |
| SCHEMBL8156564 | 0.75 | GLS (0.56) | CNR2ACHECNR1PLA2G2AMCHR1 | |
| SCHEMBL14923447 | 0.74 | CNR2 (0.52) | CNR2ACHECNR1LMNAL3MBTL1 | |
| SCHEMBL5443540 | 0.74 | CNR2 (0.55) | CNR2ACHECNR1LMNAMEN1 | |
| SCHEMBL15345011 | 0.74 | L3MBTL1 (0.52) | CNR2ACHECNR1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047694-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035146-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-07-15 | — | — | WO | disclosed |