Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RGS12 | O14924 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8140548 | 0.90 | HTR6 (0.40) | HTR6P2RX3GRIA1GRIA2GRIA3 | |
| SCHEMBL4393716 | 0.89 | HTR6 (0.43) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8133241 | 0.89 | HTR6 (0.43) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4401527 | 0.89 | HTR6 (0.43) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6607562 | 0.89 | HTR6 (0.39) | HTR6P2RX3GRIA1GRIA2GRIA3 | |
| SCHEMBL6607933 | 0.87 | HTR6 (0.38) | HTR6P2RX3GRIA1GRIA2GRIA3 | |
| SCHEMBL6607625 | 0.86 | HTR6 (0.37) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6608854 | 0.86 | HTR6 (0.37) | HTR6P2RX3GRIA1GRIA2GRIA3 | |
| Hydrochloric Acid SCHEMBL6607627 | 0.86 | HTR6 (0.37) | HTR6P2RX3GRIA1GRIA2GRIA3 | |
| SCHEMBL30259939 | 0.86 | HTR6 (0.47) | HTR6P2RX3GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781285-B1 | FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE AS GLUTAMATE ANTAGONISTS | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | claimed |
| EP-0781285-B1 | FUSED INDOLE AND QUINOXALINE DERIVATIVES, THEIR PREPARATION AND USE AS GLUTAMATE ANTAGONISTS | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| US-5801174-A | CEREBROVASCULAR DISORDERS | NEUROSEARCH A/S (DK) | 1998-09-01 | — | — | US | disclosed |