SCHEMBL8133240

SCHEMBL8133240

CC(O[Si](C)(C)C(C)(C)C)C1C(=O)N2C(C(=O)O)=C(CO)SC12

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 0.40
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
PTGS1 P23219 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7831926 1.00 ELANE (0.40) ELANEMEN1KMT2APTGS1
SCHEMBL7565158 0.90 ELANE (0.41) ELANEMEN1KMT2APTGS1
SCHEMBL10350771 0.89 ELANE (0.38) ELANEMEN1KMT2APTGS1
SCHEMBL1387498 0.88 ELANE (0.38) ELANE
SCHEMBL10349639 0.86 ELANE (0.37) ELANEMEN1KMT2APTGS1
SCHEMBL10349838 0.86 ELANE (0.37) ELANEMEN1KMT2APTGS1
SCHEMBL9343120 0.85 ELANE (0.41) ELANEMEN1KMT2APTGS1
SCHEMBL10668491 0.85 ELANE (0.40) ELANE
SCHEMBL9343859 0.84 ELANE (0.42) ELANEMEN1KMT2APTGS1
SCHEMBL9343962 0.84 ELANE (0.39) ELANEMEN1KMT2APTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0525057-B1 ANTIMICROBIAL QUINOLONYL LACTAMS PROCTER & GAMBLE PHARMA (US) 2000-06-14 EP disclosed
US-5530116-A Antimicrobial quinolonyl lactams THE PROCTER & GAMBLE COMPANY (US) 1996-06-25 US disclosed
WO-1991016327-A1 ANTIMICROBIAL QUINOLONYL LACTAMS NORWICH EATON PHARMACEUTICALS, INC. (US) 1991-10-31 WO disclosed