Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12050126 | 0.95 | HPGD (0.65) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL813535 | 0.93 | HPGD (0.79) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL14442112 | 0.87 | HPGD (0.60) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL10666168 | 0.84 | HPGD (0.67) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL14134604 | 0.84 | HPGD (0.57) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL9969969 | 0.84 | TSHR (0.64) | HPGDMAPK1MAPTABCB11CYP3A4 | |
| Hydrochloric Acid SCHEMBL11161378 | 0.84 | HPGD (0.80) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL16640624 | 0.83 | MAPT (0.60) | HPGDMAPK1HSD17B10KMT2AMAPT | |
| SCHEMBL11163640 | 0.83 | HPGD (0.78) | HPGDRECQLPKMMAPK1HSD17B10 | |
| SCHEMBL13294050 | 0.82 | HPGD (0.63) | HPGDRECQLPKMMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071663-B2 | Medically acceptable formulation of a diisocyanate terminated macromer for use as an internal adhesive or sealant | ETHICON, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-7968668-B2 | Diisocyanate terminated macromer and formulation thereof for use as an internal adhesive or sealant | ETHICON INC. (US) | 2011-06-28 | — | — | US | disclosed |
| US-7728097-B2 | Method of making a diisocyanate terminated macromer | ETHICON, INC. (US) | 2010-06-01 | — | — | US | disclosed |