Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120084 | 0.88 | MEN1 (0.56) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8125037 | 0.87 | HTT (0.55) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8115513 | 0.86 | MEN1 (0.58) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8128163 | 0.85 | GAA (0.51) | KMT2AMEN1HTTSMN1; SMN2MAOB | |
| SCHEMBL8127109 | 0.82 | HTT (0.53) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8102334 | 0.81 | HTT (0.59) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8128746 | 0.81 | HTT (0.48) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8129383 | 0.77 | MEN1 (0.48) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8129095 | 0.77 | MEN1 (0.48) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8125228 | 0.77 | HTT (0.54) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006108-A1 | 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers | Cerebrus Pharmaceuticals Limited (GB) | 2000-06-07 | — | — | EP | disclosed |