Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135050 | 0.95 | SMN1; SMN2 (0.45) | BCHEHRH3CACNA1CSMN1; SMN2SIGMAR1 | |
| SCHEMBL8142869 | 0.93 | HRH3 (0.39) | BCHEGPBAR1HRH3SLC6A2HRH1 | |
| SCHEMBL8134448 | 0.93 | SMN1; SMN2 (0.43) | BCHEHRH3CACNA1CSMN1; SMN2ALDH1A1 | |
| SCHEMBL8147315 | 0.93 | SMN1; SMN2 (0.43) | BCHEHRH3HRH1KCNH2CACNA1C | |
| SCHEMBL8142969 | 0.93 | BCHE (0.45) | BCHEGPBAR1HRH3CACNA1CSMN1; SMN2 | |
| SCHEMBL8134355 | 0.93 | SMN1; SMN2 (0.40) | BCHEHRH3CACNA1CSMN1; SMN2ALDH1A1 | |
| SCHEMBL8149697 | 0.93 | SMN1; SMN2 (0.40) | BCHEHRH3CACNA1CSMN1; SMN2SIGMAR1 | |
| SCHEMBL8142255 | 0.92 | BCHE (0.42) | BCHEGPBAR1HRH3SLC6A2HRH1 | |
| SCHEMBL2863951 | 0.92 | CACNA1F (0.39) | BCHEGPBAR1HRH3CHRM2CACNA1C | |
| SCHEMBL8142281 | 0.92 | ALDH1A1 (0.46) | BCHEHRH3CHRM2CACNA1CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | claimed |
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | disclosed |