Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135050 | 0.93 | SMN1; SMN2 (0.45) | BCHESMN1; SMN2HRH3ALDH1A1SIGMAR1 | |
| SCHEMBL8134351 | 0.93 | BCHE (0.42) | BCHEMEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL8147315 | 0.92 | SMN1; SMN2 (0.43) | BCHESMN1; SMN2HRH3ALDH1A1CACNA1F | |
| SCHEMBL8134448 | 0.92 | SMN1; SMN2 (0.43) | BCHEMEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL8134355 | 0.91 | SMN1; SMN2 (0.40) | BCHEKMT2ASMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL8149697 | 0.91 | SMN1; SMN2 (0.40) | BCHESMN1; SMN2HRH3ALDH1A1SIGMAR1 | |
| SCHEMBL8142281 | 0.91 | ALDH1A1 (0.46) | BCHESMN1; SMN2HRH3ALDH1A1SIGMAR1 | |
| SCHEMBL8140123 | 0.90 | CHRNB2 (0.39) | BCHEMEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL8142966 | 0.90 | HRH3 (0.39) | BCHEMEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL8143614 | 0.89 | SMN1; SMN2 (0.41) | BCHESMN1; SMN2HRH3ALDH1A1CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | claimed |
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | disclosed |