Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17700618 | 0.80 | GLA (0.42) | KMT2ATSHRGLASMN1; SMN2LMNA | |
| SCHEMBL8125001 | 0.80 | ADRA2A (0.46) | KMT2ATSHRGLASMN1; SMN2LMNA | |
| SCHEMBL16294121 | 0.80 | GLA (0.42) | KMT2ATSHRGLASMN1; SMN2LMNA | |
| SCHEMBL16306959 | 0.80 | GLA (0.42) | KMT2ATSHRGLASMN1; SMN2LMNA | |
| SCHEMBL27159740 | 0.78 | PYCR1 (0.41) | PYCR1KMT2ATSHRGLASMN1; SMN2 | |
| SCHEMBL30816260 | 0.78 | PYCR1 (0.41) | PYCR1KMT2ATSHRGLASMN1; SMN2 | |
| SCHEMBL8135441 | 0.78 | CA1 (0.44) | POLBTDP1 | |
| SCHEMBL171703 | 0.77 | GLA (0.40) | TSHRGLASMN1; SMN2LMNAKDM4E | |
| SCHEMBL16293959 | 0.77 | GLA (0.43) | KMT2ATSHRGLASMN1; SMN2LMNA | |
| SCHEMBL16293957 | 0.77 | GLA (0.43) | KMT2ATSHRGLASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037876-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | Novartis AG (CH) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999023073-A1 | BIPHENYL DERIVATIVES AS PHARMACEUTICALS | NOVARTIS AG (CH) | 1999-05-14 | — | — | WO | disclosed |