Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 5/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL5439264 | 0.84 | POLB (0.51) | POLBLTA4HCHRNB4CHRNA3HTR6 | |
| Biphenyl SCHEMBL4430290 | 0.84 | POLB (0.51) | POLBLTA4HCHRNB4CHRNA3HTR6 | |
| SCHEMBL9015256 | 0.81 | POLB (0.57) | POLBLTA4H | |
| SCHEMBL10141198 | 0.78 | — | — | |
| SCHEMBL115932 | 0.78 | — | — | |
| SCHEMBL10141207 | 0.78 | — | — | |
| SCHEMBL145266 | 0.78 | — | — | |
| SCHEMBL19071 | 0.78 | — | — | |
| SCHEMBL7787365 | 0.78 | FDPS (0.41) | POLBCHRNB4CHRNA3GHSR | |
| Hydrochloric Acid SCHEMBL4742761 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668266-B1 | Process for preparing 1,1-diarylprolinols | MERCK & CO INC (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0962451-A2 | Chiral catalysts for reduction of ketones and process for their preparation | MERCK & CO. INC. (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0453298-B1 | Chiral catalysts for reduction of ketones and process for their preparation | MERCK & CO INC (US) | 1995-12-06 | — | — | EP | disclosed |
| US-5189177-A | Chiral boron catalysts for reduction of ketones and process for their preparation | MERCK & CO., INC. (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0453298-A2 | Chiral catalysts for reduction of ketones and process for their preparation | MERCK & CO. INC. (US) | 1991-10-23 | — | — | EP | disclosed |
| US-5039802-A | Arylation process for preparation of chiral catalysts for ketone reduction | MERCK & CO., INC. (US) | 1991-08-13 | — | — | US | disclosed |