Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | PNP | P00491 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958885 | 0.86 | TSHR (0.52) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL2557771 | 0.83 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8133362 | 0.77 | TSHR (1.00) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL1945491 | 0.76 | KDM4E (0.66) | TSHRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11362739 | 0.74 | TSHR (0.59) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL1960199 | 0.70 | ALDH1A1 (0.49) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8142359 | 0.70 | MEN1 (0.67) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL6346663 | 0.70 | ADORA2A (0.59) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL2588131 | 0.70 | TSHR (1.00) | TSHRMEN1KMT2AALDH1A1PKM | |
| SCHEMBL1944329 | 0.70 | TLR7 (0.49) | MEN1KMT2AALDH1A1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075029-A | Xanthine modulators of metabolism of cellular P-450 | CELL THERAPEUTICS, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| WO-1999035148-A1 | COMPOUNDS FOR INCREASED BIOAVAILABILITY | CELL THERAPEUTICS, INC. (US) | 1999-07-15 | — | — | WO | disclosed |