Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142439 | 0.88 | HRH2 (0.45) | KIF11HRH2ITGB3ITGAVPTPN5 | |
| SCHEMBL8134104 | 0.83 | KIF11 (0.40) | KIF11ITGB3ITGAVQPCTMAPT | |
| SCHEMBL8135720 | 0.82 | HRH2 (0.35) | HRH2QPCTHRH4HRH3CHRM1 | |
| SCHEMBL8134082 | 0.80 | KIF11 (0.38) | KIF11ITGB3ITGAVMAPTHRH4 | |
| SCHEMBL5803661 | 0.77 | KIF11 (0.39) | KIF11ITGB3ITGAVPTPN5MAPT | |
| SCHEMBL8143967 | 0.76 | NAMPT (0.41) | KIF11QPCTHRH4 | |
| SCHEMBL8129123 | 0.73 | KIF11 (0.40) | KIF11ITGB3ITGAVQPCTMAPT | |
| SCHEMBL8135699 | 0.72 | QPCT (0.44) | HRH2QPCTMAPT | |
| SCHEMBL8135702 | 0.72 | QPCT (0.44) | HRH2QPCTMAPT | |
| SCHEMBL8143183 | 0.72 | KIF11 (0.42) | KIF11ITGB3ITGAVMAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | claimed |
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |