Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136109 | 1.00 | MEN1 (0.37) | MEN1KMT2AG6PDCACNA1BAPBA1 | |
| SCHEMBL8135046 | 0.91 | HDAC3 (0.44) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL8135044 | 0.91 | HDAC3 (0.44) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL8136379 | 0.89 | ALDH1A1 (0.40) | MEN1KMT2APIK3CDPIK3R2PIK3CA | |
| SCHEMBL8136382 | 0.89 | ALDH1A1 (0.40) | MEN1KMT2APIK3CDPIK3R2PIK3CA | |
| SCHEMBL8141656 | 0.87 | MAPT (0.41) | MEN1KMT2AG6PDCACNA1BAPBA1 | |
| SCHEMBL8141659 | 0.87 | MAPT (0.41) | MEN1KMT2AG6PDCACNA1BAPBA1 | |
| SCHEMBL8135900 | 0.79 | CCNA2 (0.37) | MEN1KMT2ACCNA2CDK2CCNA1 | |
| SCHEMBL9174685 | 0.79 | CCNA2 (0.40) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL9172754 | 0.77 | PTGER1 (0.47) | CCNA2CDK2CCNA1PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001940-A1 | CONDENSED PYRAZOLE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006374-A1 | CONDENSED PYRAZOLE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | disclosed |