Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 10/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.39 |
| ▸ | PIK3R5 | Q8WYR1 | 10/20 | 0.39 |
| ▸ | PIK3R3 | Q92569 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9172754 | 0.83 | PTGER1 (0.47) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL8150161 | 0.83 | TP53 (0.40) | ALDH1A1GAA | |
| SCHEMBL9833914 | 0.83 | PTGS1 (0.44) | CCNA2CDK2CCNA1PIK3CDPIK3R2 | |
| SCHEMBL9166215 | 0.81 | CCNA2 (0.44) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL2840559 | 0.81 | TP53 (0.48) | PTGS1PTGS2 | |
| SCHEMBL9174542 | 0.81 | CCNA2 (0.40) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL8136107 | 0.79 | MEN1 (0.37) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL8136109 | 0.79 | MEN1 (0.37) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL9170592 | 0.78 | CCNA2 (0.37) | CCNA2CDK2CCNA1PTGER1PIK3CD | |
| SCHEMBL9837128 | 0.78 | ALDH1A1 (0.56) | CCNA2CDK2CCNA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5424308-A | Immunomodulating agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| EP-0347773-B1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-04-28 | — | — | EP | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347773-A1 | Condensed Pyrazole 3-oxo-propanenitrile derivatives and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-12-27 | — | — | EP | disclosed |