Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.58 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134371 | 0.82 | CYP11B1 (0.62) | CYP11B1CYP11B2FNTAPGGT1BALDH1A1 | |
| SCHEMBL8129319 | 0.82 | CYP11B2 (0.62) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL8138765 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL765399 | 0.80 | CYP11B1 (0.67) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL28469213 | 0.79 | EPHX2 (0.48) | ALDH1A1TSHRCHRM5TEAD1PPARA | |
| SCHEMBL14476244 | 0.78 | CYP11B1 (0.58) | CYP11B1CYP11B2FNTAPGGT1B | |
| SCHEMBL8131698 | 0.78 | CYP11B1 (0.58) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL1758083 | 0.78 | CYP11B1 (0.68) | CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL7660878 | 0.78 | CYP11B1 (0.57) | CYP11B1CYP11B2FNTAPGGT1BFNTB | |
| SCHEMBL7986619 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054882-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041248-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 1999-08-19 | — | — | WO | disclosed |