Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.45 |
| ▸ | STAT3 | P40763 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136260 | 0.83 | TOP2A (0.53) | TOP2ATOP2BSTAT3KDM4EALDH1A1 | |
| SCHEMBL7498887 | 0.82 | KMT2A (0.38) | TOP2ATOP2BKDM4EALDH1A1POLB | |
| SCHEMBL6213206 | 0.80 | KDM4E (0.38) | TOP2ATOP2BSTAT3KDM4EALDH1A1 | |
| SCHEMBL6217745 | 0.80 | KDM4E (0.45) | STAT3KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL6213036 | 0.80 | STAT3 (0.38) | TOP2ATOP2BSTAT3KDM4EALDH1A1 | |
| SCHEMBL6212721 | 0.80 | STAT3 (0.38) | TOP2ATOP2BSTAT3KDM4EALDH1A1 | |
| SCHEMBL6214790 | 0.78 | KDM4E (0.49) | STAT3KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL501244 | 0.78 | STAT3 (0.59) | TOP2ATOP2BSTAT3KDM4EALDH1A1 | |
| SCHEMBL10913630 | 0.77 | ALDH1A1 (0.48) | STAT3KDM4EALDH1A1POLBHSP90AA1 | |
| SCHEMBL6213861 | 0.76 | TOP2A (0.52) | TOP2ATOP2BKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401623-B1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| EP-0401623-A1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 1990-12-12 | — | — | EP | disclosed |