SCHEMBL8136302

SCHEMBL8136302

COC(=O)C(CCCCC#N)N=C(c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 1/20 0.48
KMT2A Q03164 3/20 0.40
ANPEP P15144 2/20 0.37
GAA P10253 1/20 0.36
MIF P14174 1/20 0.35
ALDH1A1 P00352 3/20 0.35
LMNA P02545 1/20 0.35
MAPK1 P28482 1/20 0.35
TSHR P16473 1/20 0.35
CTSL P07711 5/20 0.34
CTSS P25774 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8125424 1.00 AAK1 (0.48) AAK1KMT2AANPEPGAAMIF
SCHEMBL11114111 0.92 AAK1 (0.50) AAK1KMT2AANPEPGAAMIF
SCHEMBL7539409 0.91 AAK1 (0.56) AAK1KMT2AGAAMIFALDH1A1
SCHEMBL7546027 0.89 AAK1 (0.54) AAK1KMT2AGAAMIFALDH1A1
SCHEMBL25166096 0.82 AAK1 (0.50) AAK1KMT2AGAAMIFALDH1A1
SCHEMBL3247050 0.81 AAK1 (0.49) AAK1KMT2AGAAALDH1A1TSHR
SCHEMBL6030609 0.81 KMT2A (0.41) AAK1KMT2AANPEPGAAMIF
SCHEMBL11112454 0.79 AAK1 (0.46) AAK1ALDH1A1LMNAMAPK1TSHR
SCHEMBL12087979 0.78 AAK1 (0.50) AAK1KMT2AGAAMIFALDH1A1
SCHEMBL12091642 0.78 AAK1 (0.50) AAK1KMT2AGAAMIFALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0680469-B1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME BOEHRINGER INGELHEIM PHARMA (DE) 2000-04-26 EP disclosed
US-5807875-A OBESITY THERAPY DR. KARL THOMAE GMBH (DE) 1998-09-15 US disclosed
US-5616620-A HYPOTENSIVE AGENTS KARL THOMAE GMBH (DE) 1997-04-01 US disclosed
EP-0680469-A1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME Dr. Karl Thomae GmbH (DE) 1995-11-08 EP disclosed
WO-1994017035-A1 AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME DR. KARL THOMAE GMBH (DE) 1994-08-04 WO disclosed