Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306079 | 0.87 | P2RX7 (0.49) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL307748 | 0.87 | P2RX7 (0.49) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL306078 | 0.87 | P2RX7 (0.49) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL306194 | 0.81 | P2RX7 (0.43) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL306195 | 0.81 | P2RX7 (0.43) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL12702939 | 0.79 | ALDH1A1 (0.37) | P2RX7GAAALDH1A1HTTNPSR1 | |
| SCHEMBL307393 | 0.77 | P2RX7 (0.34) | P2RX7ALDH1A1HTTNPSR1L3MBTL1 | |
| SCHEMBL307392 | 0.77 | P2RX7 (0.34) | P2RX7ALDH1A1HTTNPSR1L3MBTL1 | |
| SCHEMBL307350 | 0.71 | POLB (0.46) | P2RX7ALDH1A1HTTL3MBTL1MAPK1 | |
| SCHEMBL307351 | 0.71 | POLB (0.46) | P2RX7ALDH1A1HTTL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |