Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | MAT1A | Q00266 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8144039 | 0.69 | ATM (0.42) | MAPK1MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8139014 | 0.69 | MAPK1 (0.47) | MAPK1FGFR1NOTUMALDH1A1 | |
| SCHEMBL8140211 | 0.67 | MAPK1 (0.45) | MAPK1FGFR1KCNH2ALDH1A1 | |
| SCHEMBL8136833 | 0.66 | MAPK1 (0.44) | MAPK1FGFR1KCNH2MAT2AALDH1A1 | |
| SCHEMBL8250413 | 0.62 | TSHR (0.44) | MAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10059742 | 0.62 | ALDH1A1 (0.60) | MAPK1FGFR1MEN1ALDH1A1KMT2A | |
| SCHEMBL10059490 | 0.61 | KDM4E (0.53) | MAT2AMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL22004117 | 0.60 | AHR (0.45) | MAT2AMEN1KMT2AHTR2CSLC6A4 | |
| SCHEMBL1905014 | 0.59 | POLB (0.50) | MDM2ALDH1A1SMN1; SMN2 | |
| SCHEMBL23714684 | 0.59 | BRD4 (0.39) | NOTUMBRD4CREBBPALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |