Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142857 | 0.78 | ALDH1A1 (0.53) | FGFR1COMTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8140211 | 0.76 | MAPK1 (0.45) | MAPK1FGFR1COMTKDM4EALDH1A1 | |
| SCHEMBL18947280 | 0.75 | COMT (0.53) | COMTKDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL17918809 | 0.75 | COMT (0.41) | FGFR1COMTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8136833 | 0.75 | MAPK1 (0.44) | MAPK1FGFR1COMTKDM4EALDH1A1 | |
| SCHEMBL14827200 | 0.72 | COMT (0.54) | MAPK1COMTKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8139455 | 0.71 | MAPK1 (0.44) | MAPK1FGFR1COMT | |
| SCHEMBL26003452 | 0.71 | ALDH1A1 (0.50) | FGFR1COMTKDM4EALDH1A1HPGD | |
| SCHEMBL8137208 | 0.69 | MAPK1 (0.43) | MAPK1FGFR1ALDH1A1NOTUM | |
| SCHEMBL8137002 | 0.69 | HSD17B10 (0.39) | MAPK1COMTKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |