SCHEMBL8137237

SCHEMBL8137237

CC1=C(N)Nc2cc(C(N)C(=O)OC(C)(C)CCc3ccccc3)ccc2O1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 4/20 0.35
NAAA Q02083 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6993302 0.93 ALOX5 (0.32) ALOX5
SCHEMBL6994308 0.93 CYP3A4 (0.32) ALOX5
SCHEMBL7002041 0.91 CYP3A4 (0.39) ALOX5
SCHEMBL7002397 0.91 ALOX5 (0.31) ALOX5
SCHEMBL6994386 0.90 ALOX5 (0.31) ALOX5
SCHEMBL7001571 0.90 GRM2 (0.34) ALOX5
SCHEMBL7000917 0.90 AR (0.32) ALOX5
SCHEMBL7003205 0.90 GRM2 (0.37)
SCHEMBL6998556 0.89
SCHEMBL7002153 0.89 GRM2 (0.35) ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed