SCHEMBL8137249

SCHEMBL8137249

Cc1cc(-c2c(S(C)(=O)=O)ccc(C(=O)Cl)c2Cl)on1

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
USP2 O75604 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
CSF1R P07333 6/20 0.36
MAPT P10636 7/20 0.36
TP53 P04637 4/20 0.35
LMNA P02545 1/20 0.35
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8135897 0.90 ALDH1A1 (0.48) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL6587396 0.89 KDM4E (0.40) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL8135182 0.87 MEN1 (0.41) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL5204512 0.83 KDM4E (0.43) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL8138245 0.81 CSF1R (0.37) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL8376273 0.80 CSF1R (0.33) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL2215157 0.80 CSF1R (0.33) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL6587430 0.80 ALDH1A1 (0.50) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL8377149 0.78 MAPT (0.33) KDM4EUSP2ALDH1A1TSHRCSF1R
SCHEMBL8309940 0.78 CSF1R (0.31) ALDH1A1CSF1RMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6100421-A METHYL 3-FORMYL-4-METHANESULFONYL-2-METHYLBENZOATE, USEFUL AS A STARTING MATERIAL FOR HERBICIDE MANUFACTURE NIPPON SODA CO., LTD. (JP) 2000-08-08 US disclosed
EP-0949261-A1 SUBSTITUTED PIPERIDINEDIONE DERIVATIVES AND HERBICIDES NIPPON SODA CO., LTD. (JP) 1999-10-13 EP disclosed
US-5948917-A INTERMEDIATE FOR THE PRODUCTION OF A HERBICIDALLY ACTIVE PYRAZOLE COMPOUND NIPPON SODA CO., LTD. (JP) 1999-09-07 US disclosed
EP-0891972-A1 3-(ISOXAZOL-5-YL)-SUBSTITUTED BENZOIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1999-01-20 EP disclosed