SCHEMBL8377149

SCHEMBL8377149

CCn1nc(C(=O)c2ccc(S(C)(=O)=O)c(-c3cc(C)no3)c2Cl)cc1O

nearest known ligand 0.37

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.33
TP53 P04637 3/20 0.33
CSF1R P07333 3/20 0.32
KDM4E B2RXH2 1/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
HTT P42858 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
THRB P10828 1/20 0.31
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8376273 0.89 CSF1R (0.33) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8377155 0.87 NTRK1 (0.35) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8310173 0.84 RAB9A (0.36) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8137249 0.78 KDM4E (0.39) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8135897 0.78 ALDH1A1 (0.48) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL2215157 0.77 CSF1R (0.33) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8135182 0.75 MEN1 (0.41) MAPTTP53CSF1RKDM4EUSP2
SCHEMBL8306233 0.71 SMN1; SMN2 (0.39) MAPTCSF1RKDM4EUSP2ALDH1A1
SCHEMBL8138245 0.71 CSF1R (0.37) MAPTCSF1RKDM4EUSP2ALDH1A1
SCHEMBL6587396 0.70 KDM4E (0.40) MAPTTP53CSF1RKDM4EUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5948917-A INTERMEDIATE FOR THE PRODUCTION OF A HERBICIDALLY ACTIVE PYRAZOLE COMPOUND NIPPON SODA CO., LTD. (JP) 1999-09-07 US disclosed