SCHEMBL8137286

SCHEMBL8137286

Nc1c(F)c(Oc2cc(Oc3cc(C(F)(F)F)c(F)c(N)c3F)c(C(F)(F)F)cc2F)cc(C(F)(F)F)c1F

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
AR P10275 1/20 0.31
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8144981 0.90 AR (0.31) HTR2AHTR2CARKIF11
SCHEMBL8153131 0.87 HTR2A (0.32) HTR2AHTR2CARKIF11
SCHEMBL8151762 0.84 AR (0.30) AR
SCHEMBL8145234 0.84 GLA (0.34) HTR2AHTR2CARKIF11
SCHEMBL8146014 0.83 AR (0.36) ARKIF11
SCHEMBL8152831 0.83 AR (0.36) HTR2AHTR2CARKIF11
SCHEMBL8145068 0.81 KDM4E (0.33) HTR2AHTR2CARKIF11
SCHEMBL8144223 0.81 KIF11 (0.33) HTR2AHTR2CARKIF11
SCHEMBL8152417 0.81
SCHEMBL8152648 0.80 KDM4E (0.36) HTR2AHTR2CARKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed