SCHEMBL8146014

SCHEMBL8146014

Nc1c(C(F)(F)F)ccc(Oc2cc(Oc3ccc(C(F)(F)F)c(N)c3F)c(C(F)(F)F)cc2F)c1F

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.36
KIF11 P52732 2/20 0.36
EPAS1 Q99814 1/20 0.31
MPL P40238 2/20 0.31
MAOA P21397 1/20 0.31
KDM1A O60341 1/20 0.30
GLA P06280 1/20 0.30
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8152831 0.91 AR (0.36) ARKIF11EPAS1MPLGLA
SCHEMBL8146625 0.87 MPL (0.35) ARKIF11EPAS1MPLGLA
SCHEMBL8137286 0.83 HTR2A (0.33) ARKIF11
SCHEMBL8144981 0.83 AR (0.31) ARKIF11
SCHEMBL8145826 0.81 AR (0.42) AREPAS1
SCHEMBL8152674 0.81 KIF11 (0.45) ARKIF11MPLKDM1AGLA
SCHEMBL8143492 0.80 AR (0.35) ARKIF11EPAS1MPL
SCHEMBL8151972 0.80 KIF11 (0.35) ARKIF11EPAS1
SCHEMBL8150720 0.80 MAPT (0.38) ARKIF11MPL
SCHEMBL8151762 0.80 AR (0.30) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103860-A LOW DIELECTRIC CONSTANT, EXCELLENT TRANSPARENCY, LOW HYGROSCOPICITY AND EXCELLENT PROCESSABILITY; SUBSTRATE FOR AN OPTICAL DISK, A PICK-UP LENS, A PLASTIC SUBSTRATE FOR A LIQUID CELL AND A PRISM MITSUI CHEMICALS, INC. (JP) 2000-08-15 US disclosed
US-5990261-A Organic optical component MITSUI CHEMICALS, INC. (JP) 1999-11-23 US disclosed
EP-0826717-A1 An organic optical component MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1998-03-04 EP disclosed