Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PRF1 | P14222 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881014 | 1.00 | TBXA2R (0.44) | TBXA2RPRF1MAPTMEN1KMT2A | |
| SCHEMBL8141977 | 0.81 | AKR1B1 (0.56) | PRF1MAPTKMT2ANPC1RAB9A | |
| SCHEMBL4360936 | 0.75 | AKR1B1 (0.45) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8135265 | 0.75 | AKR1B1 (0.45) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL4360929 | 0.75 | AKR1B1 (0.45) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10824721 | 0.74 | MAPT (0.59) | MAPTKMT2ANPC1RAB9AKDM4E | |
| SCHEMBL14415807 | 0.74 | HTR2B (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL11609289 | 0.74 | HTR2B (0.51) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL26522778 | 0.73 | MAPT (0.47) | PRF1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL8126089 | 0.73 | AKR1B1 (0.43) | MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549352-B1 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO KK (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5607955-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, RENAL FAILURE AND GLAUCOMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5478840-A | Imidazo(4,5-b)pyridine derivatives used as antagonism to angiotensin ii receptors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| US-5378701-A | Angiotensin II inhibitors; hypotensive agents; congestive heart and kidney failure; glaucoma | KYOWA HAKKO KOGYO (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0549352-A2 | Tricyclic compounds as angiotensin II antagonists | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |