SCHEMBL8138993

SCHEMBL8138993

O=C(C[N+](=O)[O-])Nc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.50
GRM4 Q14833 1/20 0.49
LMNA P02545 3/20 0.46
CYP3A4 P08684 2/20 0.46
ALDH1A1 P00352 2/20 0.46
CES2 O00748 1/20 0.46
ABCB11 O95342 1/20 0.46
CYP1A2 P05177 1/20 0.46
GLA P06280 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
CHRM1 P11229 1/20 0.46
CYP2C9 P11712 1/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
TBXA2R P21731 1/20 0.46
AADAC P22760 1/20 0.46
MAPK1 P28482 1/20 0.46
CYP2C19 P33261 1/20 0.46
ADRA1A P35348 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11355076 0.84 TSHR (0.54) LMNAALDH1A1GLAALOX15TSHR
SCHEMBL10995578 0.80 TSHR (0.64) LMNAALDH1A1TSHRHTTSMN1; SMN2
SCHEMBL4006280 0.80 GRM4 (0.57) ARGRM4ALDH1A1TSHRHTT
SCHEMBL7751970 0.80 AR (0.55) ARGRM4LMNATSHRHTT
SCHEMBL9892896 0.80 TSHR (0.63) ARGRM4LMNACYP3A4ALDH1A1
SCHEMBL4652739 0.77 LMNA (0.51) ARLMNACYP3A4ALDH1A1CES2
SCHEMBL1904289 0.76 AR (0.64) ARGRM4LMNAHTTMEN1
SCHEMBL572726 0.76 GAA (0.56) ALDH1A1HTTSMN1; SMN2KMT2A
Nitric Acid SCHEMBL6034732 0.75 AR (0.47) ARGRM4LMNACYP3A4ALDH1A1
Nitric Acid SCHEMBL6034740 0.75 AR (0.47) ARGRM4LMNACYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0556393-B1 FUSED PYRAZINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 2000-07-26 EP disclosed
US-5283244-A Anticonvulsants, nervous system disorders YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1994-02-01 US disclosed
EP-0556393-A1 FUSED PYRAZINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1993-08-25 EP disclosed