Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649829 | 0.94 | ALDH1A1 (0.36) | ALDH1A1GAAMAPT | |
| SCHEMBL1188522 | 0.87 | GAA (0.38) | ALDH1A1GAAMAPT | |
| SCHEMBL30833923 | 0.85 | TDP1 (0.40) | TDP1 | |
| SCHEMBL31524176 | 0.85 | TDP1 (0.40) | TDP1 | |
| SCHEMBL2647857 | 0.85 | TDP1 (0.40) | TDP1 | |
| SCHEMBL29986193 | 0.82 | TDP1 (0.40) | ALDH1A1TDP1 | |
| SCHEMBL1202161 | 0.82 | TDP1 (0.40) | ALDH1A1TDP1 | |
| SCHEMBL8111724 | 0.80 | TDP1 (0.36) | ALDH1A1GAAMAPTTDP1 | |
| SCHEMBL10845597 | 0.80 | TDP1 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL29987339 | 0.80 | TDP1 (0.39) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056746-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999037648-A1 | TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |