Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 8/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2863951 | 0.98 | CACNA1F (0.39) | HRH3BCHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL7404569 | 0.92 | POLB (0.40) | BCHESMN1; SMN2ALDH1A1SIGMAR1ABCB1 | |
| SCHEMBL8133770 | 0.91 | CACNA1F (0.39) | HRH3BCHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8141058 | 0.90 | KDM4E (0.41) | HRH3BCHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8134351 | 0.90 | BCHE (0.42) | HRH3BCHECACNA1CSMN1; SMN2ALDH1A1 | |
| SCHEMBL8141455 | 0.89 | HRH3 (0.42) | HRH3BCHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8142255 | 0.89 | BCHE (0.42) | HRH3BCHECACNA1CSMN1; SMN2ALDH1A1 | |
| SCHEMBL8133621 | 0.89 | DHFR (0.41) | HRH3BCHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8142869 | 0.89 | HRH3 (0.39) | HRH3BCHECACNA1CSMN1; SMN2ALDH1A1 | |
| SCHEMBL8135050 | 0.89 | SMN1; SMN2 (0.45) | HRH3BCHECACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | claimed |
| US-6057332-A | Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses | ASTRA AKTIEBOLAG (SE) | 2000-05-02 | — | — | US | disclosed |