Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951820 | 0.93 | MAPT (0.47) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7945241 | 0.91 | BRAF (0.48) | MAPTBRAFNTRK1 | |
| SCHEMBL7945170 | 0.91 | MAPT (0.55) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7954006 | 0.85 | MAPT (0.46) | MAPTBRAFKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8139348 | 0.84 | BRAF (0.43) | MAPTALOX15BRAFNTRK1 | |
| SCHEMBL7951754 | 0.83 | MAPT (0.55) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7951772 | 0.82 | MAPT (0.56) | MAPTALOX15ALOX12NR4A1SMN1; SMN2 | |
| SCHEMBL7953340 | 0.82 | MAPT (0.49) | MAPTBRAFNTRK1 | |
| SCHEMBL7955607 | 0.80 | MAPT (0.44) | MAPTALOX15BRAFNTRK1 | |
| SCHEMBL7945155 | 0.77 | BRAF (0.51) | BRAFCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | claimed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | claimed |