Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139348 | 0.93 | BRAF (0.43) | BRAFMAPTNTRK1RAF1 | |
| SCHEMBL8142004 | 0.91 | MAPT (0.46) | BRAFMAPTNTRK1 | |
| SCHEMBL7953340 | 0.90 | MAPT (0.49) | BRAFMAPTNTRK1RAF1 | |
| SCHEMBL7954006 | 0.90 | MAPT (0.46) | BRAFMAPTNTRK1RAF1 | |
| SCHEMBL7955607 | 0.88 | MAPT (0.44) | BRAFMAPTNTRK1 | |
| SCHEMBL7951820 | 0.83 | MAPT (0.47) | BRAFMAPTNTRK1 | |
| SCHEMBL7945155 | 0.83 | BRAF (0.51) | BRAFRAF1 | |
| SCHEMBL6602603 | 0.80 | HDAC8 (0.46) | BRAFMAPTRAF1 | |
| SCHEMBL6293655 | 0.79 | ROCK2 (0.61) | BRAFMAPTRAF1 | |
| SCHEMBL7945170 | 0.78 | MAPT (0.55) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | claimed |
| US-6245778-B1 | 1,6-naphthyridine anti-convulsants | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-06-12 | — | — | US | disclosed |
| EP-0986559-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998054184-A1 | 1,6-NAPHTHYRIDINE ANTI-CONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-03 | — | — | WO | disclosed |