Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8143132 | 1.00 | MAPT (0.41) | MAPTLMNAMAPK1ALDH1A1CASP3 | |
| SCHEMBL4714684 | 0.83 | MAPT (0.53) | MAPTLMNAMAPK1ALDH1A1CASP3 | |
| SCHEMBL7493247 | 0.83 | MAPT (0.56) | MAPTMAPK1ALDH1A1SERPINE1CYP2C19 | |
| SCHEMBL7493258 | 0.83 | MAPT (0.56) | MAPTMAPK1ALDH1A1SERPINE1CYP2C19 | |
| SCHEMBL7489599 | 0.75 | BACE1 (0.44) | MAPTLMNAALDH1A1SERPINE1CYP2C9 | |
| SCHEMBL5264109 | 0.75 | CASP3 (0.41) | LMNACASP3CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL28690247 | 0.75 | CASP3 (0.41) | CASP3CYP2C9CYP2C19CYP2D6CNR2 | |
| SCHEMBL77428 | 0.75 | CASP3 (0.41) | LMNACASP3CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL10316029 | 0.74 | GPR119 (0.60) | MAPTLMNAALDH1A1 | |
| SCHEMBL5863476 | 0.74 | MAPT (0.39) | MAPTLMNAMAPK1ALDH1A1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6011059-A | PREVENTING OR TREATING ANGINA PECTORIS, CARDIAC DYSFUNCTION, MYOCARDIAL NECROSIS, AND ARRHYTHMIA EMPLOYING THE ABOVE ACYL GUANIDINES. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-01-04 | — | — | US | disclosed |