Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ELANE | P08246 | 6/20 | 0.50 |
| ▸ | GABRP | O00591 | 2/20 | 0.47 |
| ▸ | GABRD | O14764 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.47 |
| ▸ | GABRE | P78334 | 2/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169434 | 0.84 | KDM4E (0.51) | POLBELANEGABRPGABRDGABRA1 | |
| SCHEMBL25217083 | 0.82 | ELANE (0.48) | MAPTPOLBELANEBRD4KDM4E | |
| SCHEMBL30436019 | 0.82 | ELANE (0.48) | MAPTPOLBELANEBRD4KDM4E | |
| SCHEMBL1920160 | 0.78 | MAPT (0.62) | MAPTPOLBELANEGABRPGABRD | |
| SCHEMBL11076507 | 0.76 | L3MBTL1 (0.53) | MAPTPOLBELANEGABRPGABRD | |
| SCHEMBL3517498 | 0.76 | ELANE (0.45) | ELANEGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11170110 | 0.76 | L3MBTL1 (0.47) | MAPTPOLBELANEGABRPGABRD | |
| SCHEMBL8238335 | 0.75 | MAPT (0.46) | MAPTPOLBGABRPGABRDGABRA1 | |
| SCHEMBL11164559 | 0.75 | KDM4E (0.52) | ELANEGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8137427 | 0.74 | ALDH1A1 (0.65) | MAPTPOLBELANEBRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |